KMID : 0032220080200040240
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Annals of Dermatology 2008 Volume.20 No. 4 p.240 ~ p.243
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A Case of Pigmented Mammary Paget`s Disease
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Kim Ji-Eun
Kang Myung-Seung Kim Joung-Soo Yu Hee-Joon
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Abstract
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Pigmented mammary Paget¡¯s disease is a uncommon clinicopathologic variant of mammary Paget¡¯s disease, and this mimics malignant melanoma both clinically and histopathologically. Herein, we report on a rare case of pigmented mammary Paget¡¯s disease. An 81-year-old woman presented with 2.5¡¿1 cm sized, red and brown, eczematous plaque on her right areola, and she¡¯d had this lesion for 3 years. Histopathology showed large, atypical cells with large nuclei and abundant pale cytoplasm throughout the epidermis. Dispersed melanocytes were noted in the epidermis and some of the Paget¡¯s cells contained melanin within their cytoplasm. Immunohistochemical studies demonstrated that the intraepidermal pagetoid cells were positive for cytokeratin 7; in contrast, they were negative for S-100, Periodic-acid Schiff (PAS), Alcian blue at PH 2.5, HMB-45 and carninoembryonic antigen (CEA). We recommend that pigmented mammary Paget¡¯s disease should be included in the differential diagnosis of pigmented lesions on the nipple.
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KEYWORD
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Pigmented mammary Paget`s disease
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